Why Do You Need To Undertake The AGAP Blood Test?

Why Do You Need To Undertake The AGAP Blood Test?

AGAP is the abbreviation for the term Anion Gap. It is the measurement of the ions present in your blood with either positive or negative charges. Whenever there is an excessive acid found in your blood, there is an increase in the Anion Gap. The presence of high acid in the blood is due to the unsuccessful elimination of acid through your kidneys and lungs. It is essential to undertake the AGAP blood test to monitor the level of acid in the blood.

What is AGAP Blood Test All About?

The blood test examines the presence of the electrically charged particles in your bloodstream. The test aids to diagnose any acid based issues in your system. The charged particles in your blood, like chloride, sodium, and bicarbonate provide the anion gap equation important for the healthcare to know about. The AGAP blood test can monitor the condition of acidosis and alkalosis. Mainly, acidosis is considered to be life-threatening and must be treated soon.

Symptoms of Acidic Level Imbalance In The Blood

When there is an excess level of acid in the blood, several signs show up. Some of them include:

  • You will suffer from low blood pressure.
  • The respiratory inability, where you will be unable to hold your breath
  • Fatigue or weakness
  • Abnormal heartbeat
  • Nausea or vomiting
  • Accumulation of fluid in the body or edema
  • Confusion

The Other Tests That you Might Need to Undertake

There can be several reasons involved that affects your blood’s acid-base balance. Hence, the doctor might suggest for additional tests and scans as well. They include:

  • Lactate and glucose
  • pH levels
  • Creatinine
  • Carbon dioxide
  • BUN (Blood Urea Nitrogen)

What does it mean if you have A High Anion Gap?

There are different standard ranges for anion gap, but incompatible with different laboratories. The standard rate varies between 3 to 10 mEq/L. When your range is more than 10 mEq/L, it is considered more acidic and refers that you might be suffering from acidosis. Certain conditions influence the high anion gap value in the blood.

  • Urea in the blood
  • Aspirin overdose
  • Ethylene glycol poisoning
  • Diabetic ketoacidosis

Low Anion Gap Diagnosis

It is a sporadic condition when you might have to suffer from a small anion gap. There are specific factors responsible for it.


The condition indicates that there is a low level of protein in your blood. Some of the reasons behind low protein level in the blood include:

Monoclonal and Polyclonal Gammopathy

The condition is referred as immunoglobulins, which is the presence of the excess of proteins in the blood. LG is one of the types of immunoglobulins can lead to low anion gap value. Multiple myelomas might be associated with monoclonal gammopathies. Surprisingly, there are so many inflammatory diseases that might be related to the condition, polyclonal gammopathies. To diagnose your condition, the doctor will prescribe with AGAP blood test to monitor the levels of immunoglobulins.

Intoxication of Bromide

There are some medications, both sedative and herbal with the presence of bromide. When high bromide dosage is consumed. It can interfere with the calculation of chloride in the test. Hence, the combination of low anion gap high chloride can mismatch the entire report result. You will receive a false low anion gap value. Therefore, it is better to inform the doctor regarding your medication.


In case, you are receiving the treatment for bipolar disorder, you are prescribed with lithium dosage. In fact, you have a high concentration of it. The low anion gap result can show false reports.

Error in a Laboratory Report

Last, but not the least, a doctor might recommend for another AGAP blood scanning if the lab report suggests low anion gap value. Often there are laboratory report errors that indicate low levels of anion gap value.

Treating Low Anion Gap

Having low anion gap value is a rare condition. In case, the tests have confirmed for low anion gap value, your doctor will prescribe with several other criteria. This will help in the diagnosis of the underlying factor and thereby fix low anion gap with the right treatment. In case, it is found that the cause of your lower anion gap is due to medications with ingredients like bromide or lithium, adjustment of dosages will be prescribed.

Will there be any Genre of Preparation Required for The Test?

Perhaps the best part about this blood test is that you don’t need to take any special preparations, unlike the other blood tests. But, in case, you are allergic to latex, you must inform the doctor. Furthermore, if you are under any medication, it must be given prior intimation as well. This process is mainly conducted so that there are no interferences with the test results.

Medically Reviewed By
Dr. Kaushal M. Bhavsar (MBBS, MD)Assistant Professor in Pulmonary Medicine, GMERS Medical College, Ahmedabad